Integrating Rapid Diagnostics, AI Technologies, and Omics Approaches for Sepsis Management and Antimicrobial Stewardship

Abstract

The most recent developments in microbiological diagnostics are highlighted in this review, with an emphasis on quick and precise techniques that are essential for treating critically sick patients who may have bacterial infections. Rapid, accurate diagnostic tools that go beyond conventional culture-based methods are desperately needed, especially in light of the growing problem of antibiotic resistance and the high morbidity and mortality linked to sepsis in intensive care units. Improved pathogen identification and resistance profiling are promised by emerging technologies such as sophisticated omics techniques, nucleic acid amplification, direct-from-blood testing, and quick antigen detection. Diagnostic speed and accuracy are being revolutionized by AI-enhanced techniques like SepsetER and the Sepsis ImmunoScore, as well as cutting-edge platforms like T2 magnetic resonance and nanopore sequencing. However, these techniques still depends on their incorporation into strong antimicrobial stewardship initiatives and validation through well planned clinical trials. The potential of these new technologies is rigorously evaluated in this review, along with the crucial actions needed to turn them into improved patient outcomes.