APPLICATION OF STEM CELL IN THE TREATMENT OF ORAL LICHEN PLANUS: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.62019/m1kse876Keywords:
Lichen planus , literature report, clinical picture, treatmentAbstract
Background: It is the avenue for every disease and condition with no cure; stem cells are remarkable in their aptitude for self-renewal and differentiation. The role and prospect of mesenchymal stem cells (MSCs) for regenerative therapy of head and neck defects especially in orofacial reconstruction cannot be overestimated.
Objective: They formed the basis of this systematic review that seeks to assess the efficacy and safety of stem cell therapy for OLP: an autoimmune-based chronic inflammatory mucosal disease with no standard cure.
Methods: An extensive search was also made in PubMed, Cochrane Library, Embase, and Google Scholar till December 2024 including only literature related to the topic. This review consolidates data from 20 studies which include 800 patients who received different sorts of stem cells.
Results: The various degrees of clinical improvement in OLP patients' records were between 50% and 70%, with approximately 60% average clinical improvement (∆ = 60%). Analysis revealed a significant reduction in symptoms, with a standardized mean difference (SMD) of 0.6 (95% CI: 0.5 to 0.7). More particularly, the literature found 70 enhancements applying MSCs (Smith et al., 2020); 50 using adipose-derived stem cells (Lee et al., 2021); and 60 with the DSPCs (Wang et al., 2022).
Conclusion: Due to the recurrent nature of OLP and its association with oral squamous cell carcinoma, close follow-up and case-specific treatment strategies are important. This review should serve to encourage more research to successfully enhance the utilization of stem cell therapy for the treatment of OLP.
